Peer-reviewed veterinary case report
Large animal canine endovascular ischemic stroke models: A review.
- Journal:
- Brain research bulletin
- Year:
- 2016
- Authors:
- Atchaneeyasakul, Kunakorn et al.
- Affiliation:
- Neurology Department/Interventional Division · United States
- Species:
- dog
Plain-English summary
This study looks at how researchers are using dogs to create models of ischemic stroke, which is a type of stroke caused by a blockage in blood flow to the brain. Since dogs have brains that are similar to humans, they can help scientists understand how strokes happen and test new treatments. The researchers discuss different methods for simulating strokes in dogs, including injecting materials into blood vessels to block them. However, they note that the unique blood supply in dogs can make it harder to create larger strokes for study. Overall, the review highlights the potential of using dogs to improve our understanding and treatment of strokes.
Abstract
BACKGROUND: Stroke is one of the leading causes of death and long-term disability worldwide. Recent exciting developments in the field with endovascular treatments have shown excellent outcomes in acute ischemic stroke. Prior to translating these treatments to human populations, a large-animal ischemic stroke model is needed. With the advent of new technologies in digital subtraction angiography, less invasive endovascular stroke models have been developed. Canines have gyrencephalic brain similar to human brain and accessible neurovascular anatomy for stroke model creation. Canine stroke model can be widely utilized to understand the disease process of stroke and to develop novel treatment. Less invasive endovascular internal carotid emboli injection and coil embolization methods can be used to simulate transient or permanent middle cerebral artery occlusion. Major restriction includes the extensive collateral circulation of canine cerebral arteries that can limit the stroke size. Transient internal carotid artery occlusion can decrease collateral circulation and increase stroke size to some degree. Additional method of manipulating the extent of collateral circulation needs to be studied. Other types of canine stroke models, including vertebral artery occlusion and basilar artery occlusion, can also be accomplished by endovascular thrombi injection. CONCLUSIONS: We extensively review the literature on endovascular technique of creating canine ischemic stroke models and their application in finding new therapies for ischemic stroke.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27496066/