Peer-reviewed veterinary case report
Large animal models of traumatic injury to the immature brain.
- Journal:
- Developmental neuroscience
- Year:
- 2006
- Authors:
- Duhaime, Ann-Christine
- Affiliation:
- Children's Hospital at Dartmouth · United States
Plain-English summary
This research looks at how large animals, like pigs or sheep, can be used to study brain injuries in young animals, which is less common than using smaller animals like rats. Large animals can better mimic the way young brains develop and respond to injuries, making them useful for understanding how to treat brain injuries in infants and children. The paper discusses the benefits and challenges of using these larger models and suggests ways to improve future research in this area. Overall, it highlights the importance of choosing the right model to answer specific scientific questions about brain injuries in young patients.
Abstract
Large animal models have been used much less frequently than rodent models to study traumatic brain injury. However, large animal models offer distinct advantages in replicating specific mechanisms, morphology and maturational stages relevant to age-dependent injury responses. This paper reviews how each of these features is relevant in matching a model to a particular scientific question and discusses various scaling strategies, advantages and disadvantages of large animal models for studying traumatic brain injury in infants and children. Progress to date and future directions are outlined.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16943661/