Large-Sample Genome-Wide Association Study of Resistance to Retained Placenta in U.S. Holstein Cows.

Abstract

A genome-wide association study of resistance to retained placenta (RETP) using 632,212 Holstein cows and 74,747 SNPs identified 200 additive effects with-values < 10on thirteen chromosomes but no dominance effect was statistically significant. The regions of 87.61-88.74 Mb of Chr09 about 1.13 Mb in size had the most significant effect inand other highly significant effects inand, and in or nearand. Four non-genes in this region were reported to be involved infusions in humans. Chr23 had the largest number of significant effects that peaked in, which was involved in urate metabolism and transport that could contribute to kidney disease. Thegene contained seven significant effects and was downstream of another six significant effects. Thegene also had a highly significant effect. Bothandwere associated with kidney disease. Another highly significant effect was upstream of. Thegene of Chr05 that acts in utero in germ cell and neural cell development, and hematopoiesis was upstream of a highly significant effect, contained a significant effect, and was between another two significant effects. The results of this study provided a new understanding of genetic factors underlying RETP in U.S. Holstein cows.