Peer-reviewed veterinary case report
Laryngeal squamous cell carcinoma and papilloma associated with Equus caballus papillomavirus 2 in a horse.
- Journal:
- The Journal of veterinary medical science
- Year:
- 2019
- Authors:
- Hibi, Hiroyuki et al.
- Affiliation:
- Tokachi Livestock Hygiene Service Center · Japan
- Species:
- horse
Plain-English summary
A 19-year-old Thoroughbred stallion was diagnosed with laryngeal squamous cell carcinoma (a type of cancer) and squamous papilloma (a benign tumor) after showing severe wheezing due to narrowing in his throat. Tests revealed tumors in his larynx, laryngotrachea, and guttural pouch, with some cells showing signs of a virus similar to those that can cause cancer in humans. The presence of Equus caballus papillomavirus 2 (EcPV2) DNA in the tumors suggests that this virus may play a role in the development of these lesions in horses. Overall, the findings indicate that the cancer and the benign tumor are related and may be caused by the same virus.
Abstract
A case of laryngeal squamous cell carcinoma (SCC) and squamous papilloma in a 19-year-old Thoroughbred stallion is described. The animal exhibited severe wheezing caused by laryngopharyngeal stenosis. Histological examination identified laryngeal, laryngotracheal, and guttural pouch tumor masses consisting of areas of SCC. In the epiglottic lesion, the overlying epithelium was replaced by papilloma cells, and superficial cells frequently had nuclear inclusion bodies that expressed oncoprotein E6, which is characteristic of high risk human papillomaviruses. The papillomatous epithelium was continuous with epithelium composed of SCC cells. Equus caballus papillomavirus 2 (EcPV2) DNA was detected in the guttural pouch tumor. These findings suggest that laryngeal SCC and papilloma are a continuum of EcPV2-induced neoplastic lesions in horses.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31167980/