Peer-reviewed veterinary case report
Lawsonia intracellularis-specific interferon γ gene expression by peripheral blood mononuclear cells in vaccinated and naturally infected foals.
- Journal:
- Veterinary journal (London, England : 1997)
- Year:
- 2012
- Authors:
- Pusterla, Nicola et al.
- Affiliation:
- Department of Veterinary Medicine and Epidemiology · United States
- Species:
- horse
Abstract
The cell-mediated immune response to Lawsonia intracellularis, the agent of equine proliferative enteropathy (EPE), was investigated in vaccinated and naturally infected foals. Interferon (IFN)-γ gene expression was determined in peripheral blood mononuclear cells collected from vaccinated (n=6) and control foals (n=6) every 30 days for 180 days following first vaccine administration, and from clinically affected foals (n=16) within 7-10 days of diagnosing EPE. Seroconversion (immunoperoxidase monolayer assay titer ≥60) occurred in 5/6 vaccinated foals between 60 and 90 days following the first vaccine administration and these foals remained seropositive for the remaining study period. IFN-γ gene expression in all vaccinated foals was significantly higher (P<0.05) on days 60-180 following first vaccine administration compared to IFN-γ gene expression in control foals. When IFN-γ gene transcription was compared between naturally infected and vaccinated foals, a significant difference (P<0.05) was observed only for day 0.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21689957/