Peer-reviewed veterinary case report
Leaf Extract of Aerva javanica Suppresses Excessive Growth of Granulation Tissue in Horses.
- Journal:
- Journal of equine veterinary science
- Year:
- 2020
- Authors:
- Dedar, Ramesh Kumar et al.
- Affiliation:
- Veterinary Medicine · India
- Species:
- horse
Plain-English summary
Horses can have a tough time healing wounds because they sometimes develop too much granulation tissue, which is often called proud flesh. This study found that a leaf extract from the plant Aerva javanica can help reduce this excessive tissue growth. The researchers believe that certain natural compounds in the plant, like kaempferol and ecdysteroids, might be responsible for this effect. They prepared the extract using specific laboratory techniques and found that applying it to horses not only reduced the granulation tissue but also helped restore normal skin function. Overall, the treatment was effective in managing the issue of proud flesh in horses.
Abstract
Wound healing in horses is complicated by the excessive growth of granulation tissue, commonly known as proud flesh and is similar to keloids in human beings. At present, there is no satisfactory treatment for proud flesh in horses. In this study, we, for the first time, demonstrated that leaf extract of Aerva javanica suppresses excessive growth of granulation tissue in horses. Many plant flavonoids are claimed to have antiproliferative properties. Kaempferol is a natural flavonoid containing 3-hydroxy flavone backbone found in many plants in its aglycone form and attached with various sugars. Ecdysteroids are steroidal analogs of invertebrate steroidal hormones found in plants. Both flavonoids and ecdysteroids accumulate more in plants during abiotic stress. We hypothesized that Aerva javanica may have high levels of ecdysteroids and kaempferols for surviving in stressful conditions of desert. Those kaempferols may suppress the growth of granulation tissue by their antiangiogenesis property. Ecdysteroids may control the larvae of habronema if associated with proud flesh. Extract was prepared using solvent-based fractionation and silica gel column flash chromatography. Application of the leaf extract in horses suppressed growth of granulation tissue along with restoration of normal skin function. Various purification steps and mass spectrometry were used to identify the active components in the study.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32972675/