Peer-reviewed veterinary case report
Dog with bone infection from Lecythophora hoffmannii fungus in Japan
By Sakaeyama, Shin-Ichi et al.·Published in Medical mycology·2007·Akikawa Animal Hospital. Akiru, Japan·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Lecythophora hoffmannii isolated from a case of canine osteomyelitis in Japan.
- Species:
- dog
Plain-English summary
A 2-year-old spayed female mongrel dog was brought in for limping due to a serious bone infection called osteomyelitis, which was caused by a fungus. Despite being treated with antifungal medications for five months, her condition worsened, leading to the amputation of her leg. Unfortunately, the dog later developed swelling in her lymph node and showed signs of severe weight loss. Despite further attempts to treat the infection, she was euthanized after 459 days of suffering. This case highlights a rare and severe fungal infection in dogs.
People also search for: dog limping fungal infection · osteomyelitis treatment in dogs · dog lymph node swelling causes
Abstract
A 2-year-old spayed female mongrel dog showed claudication with abnormal ossification containing fungal cells detected by biopsy. The dog was treated with ketoconazole and itraconazole perorally for 5 months; however, the osteomyelitis became aggravated, and an amputation from the scapula was performed. The right superficial cervical lymph node became swollen 5 months after the operation. The lymph node contained PAS positive fungal elements and a portion of tissue produced mycelial fungal growth on potato dextrose agar supplemented with chloramphenicol. The culture was identified as Lecythophora hoffmannii based on morphology, physiology and 100% identity in the sequence of the D1/D2 domain of the large subunit ribosomal RNA gene of the fungal species in the GenBank database (accession number AB100627). In addition, the sequence from the present isolate was submitted as AB189164. The isolate showed resistance to antifungal agents, i.e., amphotericin B, 5-FC, fluconazole, itraconazole, miconazole and micafungin. The dog developed cachexia 2 months after the onset of lymphadenopathy, and was euthanized on the 459th day after onset of clinical symptoms. This was the first disseminated case of L. hoffmannii infection in Japan.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17464847/