Peer-reviewed veterinary case report
How left heart shape affects carvedilol response in cats with HOCM
By Mochizuki, Yohei et al.·Published in The Journal of veterinary medical science·2019·Department of Veterinary Clinical Medicine, Japan·View original on PubMed →
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Original publication title: Left ventricular geometric characteristics predict response to carvedilol in cats with asymptomatic hypertrophic obstructive cardiomyopathy caused by systolic anterior motion of the mitral valve.
- Species:
- cat
Plain-English summary
A group of 16 cats with hypertrophic obstructive cardiomyopathy (HOCM), a heart condition that can cause breathing problems, were treated with a medication called carvedilol. The cats were divided into two groups: those that responded well to the treatment and those that did not. It was found that cats that didn't respond had certain heart characteristics, like a longer mitral valve and thicker heart walls, which might indicate they wouldn't benefit from carvedilol. Understanding these heart features can help vets predict which cats may not respond to this treatment.
People also search for: cat heart disease treatment · carvedilol for cats · hypertrophic obstructive cardiomyopathy symptoms in cats
Abstract
Beta-blockers are used to treat cats with hypertrophic obstructive cardiomyopathy (HOCM). However, there are various hemodynamic responses to beta-blockers. This retrospective study aimed to explore the relationship between the response to carvedilol and the presence of geometric abnormalities. Medical records were reviewed for 16 cats diagnosed with HOCM. Cats were divided into two groups based on the velocity of the left-ventricular outflow-tract after carvedilol treatment (responder: eight cats, non-responder: eight cats). Baseline intergroup comparison revealed that anterior mitral valve leaflet length and diastolic left-ventricular posterior-wall thickness were significantly greater in the non-responder group. Longer anterior mitral valve leaflet and thicker left-ventricular posterior-wall may cause poor response to carvedilol. Thus, these properties may predict a lack of response to carvedilol therapy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30944272/