Peer-reviewed veterinary case report
Leptin reduces hyperactivity in an animal model for anorexia nervosa via the ventral tegmental area.
- Journal:
- European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
- Year:
- 2011
- Authors:
- Verhagen, Linda A W et al.
- Affiliation:
- Rudolf Magnus Institute of Neuroscience · Netherlands
Abstract
Hyperactivity in anorexia nervosa (AN) is associated with low plasma leptin levels and negatively impacts on disease outcome. Using an animal model that mimics features of AN including food-restriction induced hyperlocomotion, we demonstrate that central leptin injections in the lateral ventricle and local injections of leptin into the ventral tegmental area (VTA) suppress running wheel activity. The results support that falling levels of leptin, that accompany caloric restriction, result in increased activity levels because of decreased leptin signaling in the VTA, part of the mesolimbic reward system.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21190812/