Peer-reviewed veterinary case report
Blood cell changes in dogs after low-dose LPS injection
By Flatland, B et al.Ā·Published in Research in veterinary scienceĀ·2011Ā·Department of Pathobiology, United StatesĀ·View original on PubMed ā
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Original publication title: Leukocyte and platelet changes following low-dose lipopolysaccharide administration in five dogs.
- Species:
- dog
Plain-English summary
Five dogs were given a low dose of a substance called lipopolysaccharide (LPS) to see how it affected their blood cells. After the treatment, the dogs showed some mild changes in their white blood cells and platelets, but they didn't have any severe symptoms or health issues. Blood tests revealed that their white blood cell counts dropped at first but then increased after 24 hours. The study suggests that even a small amount of LPS can cause noticeable changes in blood cell counts in dogs without leading to serious problems.
People also search for: dog blood test results Ā· low platelet count in dogs Ā· effects of lipopolysaccharide in dogs
Abstract
Effects of low-dose LPS (0.1 μg/kg i.v.) on leukocyte and platelet parameters measured using an Advia 120 hematology analyzer were investigated. Five dogs received a saline sham treatment prior to LPS, and blood was collected before and 3, 6, and 24 h post-treatment. LPS-treated dogs had mild neutrophil toxic change and increased neutrophil bands at 3 and 6 h. Compared to saline-treated controls, total leukocyte, neutrophil, and monocyte counts of LPS-treated dogs were significantly decreased at 3 h and increased at 24 h. Compared to baseline, total leukocyte counts of LPS-treated dogs were significantly decreased at 3 h and increased at 24 h. Mean platelet volume was significantly increased and mean platelet component concentration was decreased at 3 h compared to baseline. Platelet count was significantly decreased at 3 and 6 h; plateletcrit did not change significantly. High dosage is not required in order to detect LPS-mediated hematologic effects in dogs. Low-dose LPS administration causes significant changes in leukocyte and platelet indices in dogs without causing severe clinical signs or death.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20965082/