Peer-reviewed veterinary case report
Lifespan of male and female APP/PS1 and APPmouse models of Alzheimer's disease.
- Journal:
- Journal of Alzheimer's disease : JAD
- Year:
- 2025
- Authors:
- Roberts, Hannah et al.
- Affiliation:
- Neuroscience Institute · United States
Abstract
Alzheimer's disease (AD) disproportionately affects women, yet most preclinical research studies are male-centric. We performed lifespan analyses of male and female AD mouse models (APP/PS1 and APP) and their shared genetic background control (C57BL/6). Survival curves support significant sex differences between genotypes. Minimal longevity revealed increased age in male APP/PS1, and decreased age in male APPmice. Maximal longevity revealed an increased average age in males. Furthermore, median lifespan differed between sex and genotype. This study supports dimorphic survival in two mouse models of AD, emphasizing the need to examine mechanisms and treatments in both sexes.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/40138433/