Peer-reviewed veterinary case report
Light-chain multiple myeloma diagnosed in an 11-year-old cat
By Yamada, Osamu et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2007·Department of Veterinary Clinical Pathology, Japan·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Light-chain multiple myeloma in a cat.
- Species:
- cat
Plain-English summary
An 11-year-old male American Shorthair cat was diagnosed with light-chain multiple myeloma, a type of cancer affecting the plasma cells in the bone marrow. The cat showed signs of abnormal protein levels in the blood and urine, which were confirmed through specialized tests. The tests revealed that the cancerous cells were producing only light chains of immunoglobulin, rather than the usual heavy chains. Unfortunately, the abstract does not provide information on treatment or the outcome for this cat.
People also search for: cat cancer symptoms · light-chain multiple myeloma in cats · cat blood protein levels · American Shorthair cancer treatment
Abstract
A diagnosis of light-chain multiple myeloma was made in an 11-year-old male American Shorthair cat. The cat showed atypical plasma cell infiltration in the bone marrow, biclonal gammopathy caused by polymerization of myeloma protein (M-protein), and Bence-Jones proteinuria. The M-protein in the serum of the cat was analyzed by using 12% sodium dodeyl sulfate (SDS) polyacrylamide gel electrophoresis with Coomassie brilliant blue staining. An intense band with a size of 27 kDa, the size of the immunoglobulin light chain, was clearly observed, whereas the band corresponding to the immunoglobulin heavy chain (59 kDa) was undetectable. The 27-kDa band was confirmed to be an immunoglobulin light chain by Western blotting by using antibodies for feline immunoglobulin. These data suggested that the neoplastic plasma cells produce light chain only, leading to the diagnosis of light-chain multiple myeloma in the cat.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17609361/