Peer-reviewed veterinary case report
Limited hepatitis B virus replication space in the chronically hepatitis C virus-infected liver.
- Journal:
- Journal of virology
- Year:
- 2014
- Authors:
- Wieland, S F et al.
- Affiliation:
- Department of Immunology and Microbial Science · United States
Abstract
We compared the kinetics and magnitude of hepatitis B virus (HBV) infection in hepatitis C virus (HCV)-naive and chronically HCV-infected chimpanzees in whose livers type I interferon-stimulated gene (ISG) expression is strongly induced. HBV infection was delayed and attenuated in the HCV-infected animals, and the number of HBV-infected hepatocytes was drastically reduced. These results suggest that establishment of HBV infection and its replication space is limited by the antiviral effects of type I interferon in the chronically HCV-infected liver.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24522924/