Peer-reviewed veterinary case report
Limits of a localized magnetic resonance spectroscopy assay for ex vivo myocardial triacylglycerol.
- Journal:
- Journal of pharmaceutical and biomedical analysis
- Year:
- 2007
- Authors:
- O'Connor, Robert D et al.
- Affiliation:
- Department of Radiology · United States
Abstract
Localized magnetic resonance spectroscopy (LMRS) promises a powerful non-invasive means to determine myocardial triacylglycerol (TAG) in a clinical setting. Here, the linearity, specificity, robustness, precision, and accuracy of an ex vivo mouse-heart LMRS TAG assay are assessed by quantifying the spatial, spectral, and relaxation-induced uncertainties. The protocol, which is based on localization by adiabatic selective refocusing (LASER) using frequency offset corrected inversion (FOCI) pulses, alternating gradient polarity, and simple post-processing, is shown to have good characteristics. The presented protocol has a benchmark, phantom-based, accuracy of 3%, and when applied to ex vivo mouse hearts the accuracy is 6%, making the LMRS assay comparable to the typical destructive bioanalytical assay.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17931816/