Peer-reviewed veterinary case report
Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice.
- Journal:
- Fertility and sterility
- Year:
- 2011
- Authors:
- Elia, Evelin M et al.
- Affiliation:
- Centro de Estudios Farmacoló
- Species:
- rodent
Abstract
Chronic hyperandrogenism alters the peroxisome proliferator-activated receptor γ (PPARγ) pathway in the uterine tissue of prepubertal mice. The gene and protein expression of PPARγ is not modified, but the gene and protein expression of 12-lipoxygenase (12-LOX), an enzyme that synthesizes PPARγ ligands, is decreased. The antihyperglycemic drug metformin can prevent this adverse effect.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21382619/