Peer-reviewed veterinary case report
Gene linked to high uric acid in Dalmatian dog urine mapped
By Safra, Noa et al.·Published in Mammalian genome : official journal of the International Mammalian Genome Society·2006·Department of Population Health and Reproduction School of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: Linkage analysis with an interbreed backcross maps Dalmatian hyperuricosuria to CFA03.
- Species:
- dog
Plain-English summary
A study found that all Dalmatians have a genetic condition called hyperuricosuria, which means they excrete high levels of uric acid in their urine instead of allantoin like most other dogs. This condition can lead to the formation of painful urinary stones. Researchers identified a specific genetic marker linked to this trait, which could help in understanding and managing the risk of urinary issues in Dalmatians. Knowing about this genetic predisposition can help owners take preventive measures to keep their pets healthy.
People also search for: Dalmatian urinary stones · hyperuricosuria in dogs · how to prevent urinary stones in Dalmatians
Abstract
Dalmatians, like humans, excrete uric acid in their urine. All other dogs and most mammals excrete allantoin, a water-soluble compound that is further along the purine degradation pathway. Excretion of uric acid at high concentrations (hyperuricosuria) predisposes Dalmatians to the formation of urinary urate calculi. Hyperuricosuria (huu) is found in all Dalmatians tested and is inherited as an autosomal recessive trait. A genome scan and linkage analysis performed on a Dalmatian x Pointer interbreed backcross detected a single linked marker, REN153P03, located on CFA03. Haplotype analysis of the region around this marker defined a 3.3-Mb interval flanked by single recombination events. This interval, which contains the huu mutation, is estimated to include 24 genes.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16596455/