Peer-reviewed veterinary case report
Lipid-lowering properties of 6-benzoyl-2(3H)-benzothiazolone and structurally related compounds.
- Journal:
- Journal of enzyme inhibition and medicinal chemistry
- Year:
- 2005
- Authors:
- Yous, Saïd et al.
- Affiliation:
- Laboratoire de Chimie Thé · France
- Species:
- rodent
Abstract
Fifteen compounds derived from the 2(3H)-benzothiazolone template with an acyl side-chain in position-6 were evaluated for their lipid-lowering action in mice. Among these compounds, 6-benzoyl-2(3H)-benzothiazolone was found to be the most potent one both in mice models receiving a hypercholesterolemic diet (for 15 days) or a standard diet (for 21 days). 6-Benzoyl-2(3H)-benzothiazolone compares favorably with fenofibrate, the standard drug, both in terms of HDL-C/Chol (High Density Lipoprotein-Cholesterol/Total Cholesterol) ratio and absence of liver hepatomegaly.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16408788/