Peer-reviewed veterinary case report
Lipid metabolites and nitric oxide production in the cerebrospinal fluid and plasma of dogs with meningoencephalitis of unknown origin and idiopathic epilepsy: a pilot study.
- Journal:
- Frontiers in veterinary science
- Year:
- 2024
- Authors:
- Yonezawa, Tomohiro et al.
- Affiliation:
- Graduate School of Agricultural and Life Sciences · Japan
- Species:
- dog
Plain-English summary
This study looked at dogs with two brain conditions that can cause seizures: idiopathic epilepsy (a type of epilepsy with no known cause) and meningoencephalomyelitis of unknown origin (a brain inflammation with an unclear cause). Researchers measured certain substances in the fluid around the brain and in the blood of healthy dogs and those with these conditions. They found differences in specific lipid metabolites (fat-related substances) and levels of nitric oxide, which may help in diagnosing these brain diseases. While it's not clear if these changes are a cause or a result of the conditions, they could potentially be useful for diagnosis and treatment. Overall, the findings suggest that these substances might help in understanding and managing epilepsy in dogs.
Abstract
INTRODUCTION: Idiopathic epilepsy (IE) and meningoencephalomyelitis of unknown origin (MUO) are common causes of brain diseases leading to seizures in dogs. In this study, the concentrations of 196 lipid metabolites and nitrogen oxide (NO) production in the cerebrospinal fluid (CSF) and plasma of dogs with MUO or IE were measured using a LC-MS/MS and a NOx analyzer, respectively. METHODS: Nine clinically healthy dogs and 11 and 12 dogs with IE and MUO, respectively, were included in the study. RESULTS: Lipid analysis revealed variations in the levels of four and six lipid metabolites in CSF and plasma, respectively, between the groups. The levels of 6-keto-prostaglandin (PG) F1(PGF1), 20-carboxy arachidonic acid (20-carboxy-AA), 9-hydroxyoctadecadienoic acid, and lyso-platelet-activating factor were high in the CSF of dogs with MUO. In addition, the plasma levels of 11,12-dihydroxyeicosatrienoic acid, 20-carboxy-AA, and oleoylethanolamide were high in dogs with IE, and those of PGF1were high in dogs with MUO. NO production levels were high in CSF but not in plasma in dogs with MUO or IE. DISCUSSION: It remains unknown whether these changes represent the cause or effect of diseases of the central nervous system; however, lipid metabolites and NO production in CSF and plasma may be used as diagnostic biomarkers and could be exploited for treating idiopathic or inflammatory epilepsy in dogs.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/38983766/