Peer-reviewed veterinary case report
Lipid and nitric oxide changes in dogs with brain inflammation
By Yonezawa, Tomohiro et al.·Published in Frontiers in veterinary science·2024·Graduate School of Agricultural and Life Sciences, Japan·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Lipid metabolites and nitric oxide production in the cerebrospinal fluid and plasma of dogs with meningoencephalitis of unknown origin and idiopathic epilepsy: a pilot study.
- Species:
- dog
Plain-English summary
A group of dogs with seizures, including some with idiopathic epilepsy (a type of epilepsy with no known cause) and others with meningoencephalitis of unknown origin (a brain inflammation), were studied to understand changes in certain fats and nitric oxide in their bodies. The researchers found that dogs with meningoencephalitis had higher levels of specific lipid metabolites in their cerebrospinal fluid, while those with idiopathic epilepsy showed different changes in their blood. Although it's unclear if these changes cause the conditions or are a result of them, they might help in diagnosing and treating these brain diseases in dogs.
People also search for: dog seizures treatment · idiopathic epilepsy in dogs · meningoencephalitis symptoms in dogs
Abstract
INTRODUCTION: Idiopathic epilepsy (IE) and meningoencephalomyelitis of unknown origin (MUO) are common causes of brain diseases leading to seizures in dogs. In this study, the concentrations of 196 lipid metabolites and nitrogen oxide (NO) production in the cerebrospinal fluid (CSF) and plasma of dogs with MUO or IE were measured using a LC-MS/MS and a NOx analyzer, respectively. METHODS: Nine clinically healthy dogs and 11 and 12 dogs with IE and MUO, respectively, were included in the study. RESULTS: Lipid analysis revealed variations in the levels of four and six lipid metabolites in CSF and plasma, respectively, between the groups. The levels of 6-keto-prostaglandin (PG) F1(PGF1), 20-carboxy arachidonic acid (20-carboxy-AA), 9-hydroxyoctadecadienoic acid, and lyso-platelet-activating factor were high in the CSF of dogs with MUO. In addition, the plasma levels of 11,12-dihydroxyeicosatrienoic acid, 20-carboxy-AA, and oleoylethanolamide were high in dogs with IE, and those of PGF1were high in dogs with MUO. NO production levels were high in CSF but not in plasma in dogs with MUO or IE. DISCUSSION: It remains unknown whether these changes represent the cause or effect of diseases of the central nervous system; however, lipid metabolites and NO production in CSF and plasma may be used as diagnostic biomarkers and could be exploited for treating idiopathic or inflammatory epilepsy in dogs.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38983766/