Peer-reviewed veterinary case report
Lipoprotein and cholesterol levels in Miniature Schnauzers with high
By Bunn, Troy et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2024·Western Australian Veterinary Emergency and Specialty, Australia·View original on PubMed →
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Original publication title: Lipoprotein profiles in Miniature Schnauzer dogs with idiopathic hypertriglyceridemia and hypercortisolism.
- Species:
- dog
Plain-English summary
A group of Miniature Schnauzers with high triglycerides (iHTG) and those with high cortisol levels (hypercortisolism) were studied to understand their cholesterol and fat profiles. The dogs with iHTG had higher cholesterol levels compared to healthy dogs, and those with both high cortisol and triglycerides had even higher cholesterol levels than those with just high cortisol. Unfortunately, it was difficult to tell the difference between dogs with iHTG and those with high cortisol based on their fat profiles alone. This means that diagnosing iHTG often requires ruling out other conditions first.
People also search for: Miniature Schnauzer high triglycerides treatment · dog hypercortisolism symptoms · Schnauzer cholesterol levels
Abstract
Miniature Schnauzer dogs (MSs) are predisposed to both idiopathic hypertriglyceridemia (iHTG) and hypercortisolism (HCort). To our knowledge, the lipoprotein profiles of MSs with iHTG have not been compared to those with HCort. We analyzed cholesterol and triglyceride concentrations and lipoprotein fractions in 4 groups of MSs: normotriglyceridemia (NTG) without concurrent disease (Healthy-NTG), HCort and NTG (HCort-NTG), HCort and HTG (HCort-HTG), and iHTG. Lipoprotein fractions were assessed by lipoprotein electrophoresis and compared between groups. Fifty-one plasma samples were analyzed. Twenty-five dogs had NTG (16 Healthy-NTG, 9 HCort-NTG) and 26 dogs had HTG (7 iHTG, 19 HCort-HTG). Dogs with iHTG or HCort-HTG had significantly higher cholesterol concentrations than Healthy-NTG dogs. Dogs with HCort-HTG had higher cholesterol than HCort-NTG dogs. There was a significantly higher low-density lipoprotein (LDL) percentage in iHTG and HCort-HTG dogs than HCort-NTG dogs. HCort-HTG dogs also had lower high-density lipoproteins (HDL) than HCort-NTG dogs. It was not possible to readily distinguish MSs with iHTG from MSs with HCort-HTG or Healthy-NTG using lipoprotein electrophoresis fractions. The diagnosis of iHTG remains a diagnosis by exclusion.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38111301/