Peer-reviewed veterinary case report
Liver changes and enzyme rises in dogs with pancreatic insufficiency
By Adamama-Moraitou, K K et al.Ā·Published in Canadian journal of veterinary research = Revue canadienne de recherche veterinaireĀ·2004Ā·Department of Clinical Studies School of Veterinary MedicineĀ·View original on PubMed ā
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Original publication title: Liver biochemical and histopathological findings in dogs with experimentally induced exocrine pancreatic insufficiency.
- Species:
- dog
Plain-English summary
A group of dogs with exocrine pancreatic insufficiency (EPI), a condition where the pancreas doesn't produce enough digestive enzymes, showed elevated liver enzyme levels during a study. This was confirmed through blood tests and liver tissue examination, which also revealed fat buildup in the liver. The findings suggest that dogs with EPI may also have liver issues, so it's important for veterinarians to check liver function in these cases. Addressing both conditions may require different treatments to ensure the dog's health.
People also search for: dog exocrine pancreatic insufficiency symptoms Ā· elevated liver enzymes in dogs Ā· EPI treatment for dogs
Abstract
Routine liver biochemical parameters were evaluated in 8 dogs with exocrine pancreatic insufficiency (EPI) induced by surgical ligation of the pancreatic duct and the pancreatic branch of the pancreaticoduodenal artery and confirmed with the trypsin-like immunoreactivity test. Eight additional dogs were used as healthy controls. Data collection began at the 4th week postoperatively and continued weekly to the 21st week. In the dogs with EPI, the serum activity of alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase were consistently elevated. The serum total and conjugated bilirubin concentrations remained within normal limits throughout the experimental period. Histopathological study revealed hepatic lipidosis in the dogs with EPI. Therefore, since this condition seems to be an additional consequence of EPI in dogs, laboratory evaluation of dogs with EPI must include assessment of liver function, to determine if additional or different therapeutic measures are indicated.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/14979436/