Peer-reviewed veterinary case report
Changes in skin and blood fats linked to dog atopic dermatitis
By Franco, Jackeline et al.·Published in Metabolites·2021·Department of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907, USA, United States·View original on Crossref →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Local and Systemic Changes in Lipid Profile as Potential Biomarkers for Canine Atopic Dermatitis
- Species:
- dog
Plain-English summary
A study found that dogs with atopic dermatitis (a skin allergy) showed significant differences in the fats (lipids) in their skin and blood compared to healthy dogs. This suggests that the skin condition is linked to changes in the dog's overall metabolism. Treatments like oclacitinib and lokivetmab helped improve the skin condition and also altered the lipid levels in both skin and blood. The researchers identified specific lipid patterns that could help diagnose atopic dermatitis accurately.
People also search for: dog skin allergy treatment · atopic dermatitis in dogs · oclacitinib for dog skin problems
Abstract
Lipids play a critical role in the skin as components of the epidermal barrier and as signaling and antimicrobial molecules. Atopic dermatitis in dogs is associated with changes in the lipid composition of the skin, but whether these precede or follow the onset of dermatitis is unclear. We applied rapid lipid-profiling mass spectrometry to skin and blood of 30 control and 30 atopic dogs. Marked differences in lipid profiles were observed between control, nonlesional, and lesional skin. The lipid composition of blood from control and atopic dogs was different, indicating systemic changes in lipid metabolism. Female and male dogs differed in the degree of changes in the skin and blood lipid profiles. Treatment with oclacitinib or lokivetmab ameliorated the skin condition and caused changes in skin and blood lipids. A set of lipid features of the skin was selected as a biomarker that classified samples as control or atopic dermatitis with 95% accuracy, whereas blood lipids discriminated between control and atopic dogs with 90% accuracy. These data suggest that canine atopic dermatitis is a systemic disease and support the use of rapid lipid profiling to identify novel biomarkers.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on Crossref: https://doi.org/10.3390/metabo11100670