Peer-reviewed veterinary case report
Minocycline nanoparticles improve periodontitis treatment in dogs
By Yao, Wenxin et al.·Published in International journal of nanomedicine·2014·Fudan University, China·View original on PubMed →
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Original publication title: Local delivery of minocycline-loaded PEG-PLA nanoparticles for the enhanced treatment of periodontitis in dogs.
- Species:
- dog
Plain-English summary
A group of beagle dogs with chronic gum disease (periodontitis) were treated with special nanoparticles loaded with a medication called minocycline, which helps fight infections. These nanoparticles were designed to stay in the gums longer than traditional treatments, allowing the medicine to work more effectively. After treatment, the dogs showed a significant reduction in symptoms of periodontitis compared to those treated with standard options. This new method could be a promising way to manage gum disease in dogs.
People also search for: dog gum disease treatment · beagle periodontitis symptoms · minocycline for dogs dental health
Abstract
BACKGROUND: Rapid local drug clearance of antimicrobials is a major drawback for the treatment of chronic periodontitis. In the study reported here, minocycline-loaded poly(ethylene glycol)-poly(lactic acid) nanoparticles were prepared and administered locally for long drug retention and enhanced treatment of periodontitis in dogs. METHODS: Biodegradable poly(ethylene glycol)-poly(lactic acid) was synthesized to prepare nanoparticles using an emulsion/solvent evaporation technique. The particle size and zeta potential of the minocycline-loaded nanoparticles (MIN-NPs) were determined by dynamic light scattering and the morphology of the nanoparticles was observed by transmission electron microscopy. The in vitro release of minocycline from MIN-NPs and in vivo pharmacokinetics of minocycline in gingival crevice fluid, after local administration of MIN-NPs in the periodontal pockets of beagle dogs with periodontitis, were investigated. The anti-periodontitis effects of MIN-NPs on periodontitis-bearing dogs were finally evaluated. RESULTS: Transmission electron microscopy examination and dynamic light scattering results revealed that the MIN-NPs had a round shape, with a mean diameter around 100 nm. The in vitro release of minocycline from MIN-NPs showed a remarkably sustained releasing characteristic. After local administration of the MIN-NPs, minocycline concentration in gingival crevice fluid decreased slowly and retained an effective drug concentration for a longer time (12 days) than Periocline(®). Anti-periodontitis effects demonstrated that MIN-NPs could significantly decrease symptoms of periodontitis compared with Periocline and minocycline solution. These findings suggest that MIN-NPs might have great potential in the treatment of periodontitis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25170266/