Peer-reviewed veterinary case report
Local targeting NF-κB in the lung tissue of TB-infected mice diminishes the level of pathology.
- Journal:
- Tuberculosis (Edinburgh, Scotland)
- Year:
- 2017
- Authors:
- Shepelkova, Galena et al.
- Affiliation:
- Department of Immunology
- Species:
- rodent
Abstract
Mice of the genetically TB-susceptible strain I/St were infected with ∼100 CFU of Mycobacterium tuberculosis strain H37Rv, and after week 3 post-infection treated by inhalations of the NBD peptide selectively blocking NF-κB activation pathway. This therapy resulted in a pronounced attenuation of lung pathology and down-regulation of the expression of several genes encoding major inflammatory molecules, but did not diminish the level of mycobacterial multiplication in the lungs.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28237038/