Peer-reviewed veterinary case report
Lomustine and prednisone chemo for high-grade dog mast cell tumors
By Hay, Jennifer K & Larson, Victoria S·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2019·CARE Centre, Canada·View original on PubMed →
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Original publication title: Lomustine (CCNU) and prednisone chemotherapy for high-grade completely excised canine mast cell tumors.
- Species:
- dog
Plain-English summary
Fifteen dogs with high-grade mast cell tumors (a type of skin cancer) that had been completely removed were treated with a combination of lomustine (CCNU) and prednisone. While some dogs experienced treatment failures due to tumor recurrence or spread, the overall survival time was promising, with many dogs living over two years after treatment. Most dogs had some side effects, like low white blood cell counts and liver enzyme increases, but none required hospitalization. This treatment combination appears to be a viable option for managing high-grade mast cell tumors in dogs.
People also search for: dog mast cell tumor treatment · lomustine for dogs · prednisone side effects in dogs
Abstract
The efficacy and toxicity of lomustine and prednisone for treating high-grade completely excised mast cell tumors (MCTs) was evaluated in a retrospective study of 15 dogs. Dogs were treated with lomustine (CCNU) at 70 mg/mevery 4 weeks and prednisone at 0.5 to 1 mg/kg body weight PO daily. Eight dogs had treatment failures due to recurrence at the site of the initial surgery (2/15),cutaneous MCT (4/15), or metastatic disease (2/15). The median overall survival time was 904 days, with 9 dogs alive at 1 year and 6 dogs alive after 2 years. All but 2 of the dogs had toxicity throughout their treatment protocol, with neutropenia (67%) and elevations in ALT (60%) being the most common; however, no dogs required hospitalization. The protocol was overall well-tolerated and lomustine/prednisone should be considered in the adjunctive treatment of high-grade mast cell tumors.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31814640/