Peer-reviewed veterinary case report
Lomustine helped shrink gastrointestinal mast cell tumor in boxer dog
By Baldi, A et al.·Published in The Journal of small animal practice·2006·S A F U Department, Italy·View original on PubMed →
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Original publication title: Lomustine for the treatment of gastrointestinal mast cell tumour in a dog.
- Species:
- dog
Plain-English summary
An eight-year-old male boxer was diagnosed with a large, inoperable mast cell tumor in his abdomen that had spread to nearby lymph nodes. After surgery, he was treated with a combination of lomustine and prednisone, which led to a quick improvement in his activity level, weight gain, and a significant reduction in tumor size. He remained in partial remission for seven months, meaning the tumor shrank by more than half. Unfortunately, he later developed a serious infection related to the chemotherapy, and due to financial concerns, his owners chose to euthanize him, even though the tumor was still responding to treatment.
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Abstract
An eight-year-old, male boxer dog was referred for the treatment of a large (5.5 x 5 cm), unresectable visceral mast cell tumour. The dog had a surgical resection performed one month before referral, and it had widespread metastases to the abdominal lymph nodes. The patient was treated with lomustine and prednisone and showed a rapid improvement and increased level of activity, weight gain and consistent tumour reduction. The patient remained in partial remission (defined as a greater than 50 per cent reduction in tumour volume) for seven months. Toxicity was acceptable and was limited to moderate anaemia and two episodes of neutropenia. At the completion of the seven months of therapy, the dog experienced a chemotherapy-induced sepsis, and the owners elected for euthanasia due to financial concerns. At that time, the tumour was still in partial remission. This case report suggests that a combination of lomustine and prednisone is an effective protocol for the palliation of aggressive visceral mast cell tumours.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16911116/