Peer-reviewed veterinary case report
Long-lasting immunity by early infection of maternal-antibody-protected infants.
- Journal:
- European journal of immunology
- Year:
- 2010
- Authors:
- Navarini, Alexander A et al.
- Affiliation:
- Institute for Experimental Immunology
- Species:
- rodent
Abstract
Newborn higher vertebrates are largely immuno-incompetent and generally survive infections--including poxviruses--by maternal antibody protection. Here, we show that mice survived epidemics as adults only if exposed to lethal orthopoxvirus infections during infancy under the umbrella of maternal protective antibodies. This implies that both the absence of exposure to infection during early infancy or of effective vaccination renders the population highly susceptible to new or old re-emerging pathogens.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19877011/