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Peer-reviewed veterinary case report

Long-term case study of myelodysplastic syndrome in a dog.

Journal:
Journal of the American Animal Hospital Association
Year:
1999
Authors:
Miyamoto, T et al.
Affiliation:
Department of Veterinary Medicine · Japan
Species:
dog

Abstract

A 10-year-old, female shih tzu was diagnosed as having myelodysplastic syndrome (MDS) based on the presence of a nonregenerative anemia, dysplastic changes in the three hematopoietic cell lines, a normal to hypercellular bone marrow, and less than 30% blast cells of all nucleated cells in the bone marrow. Low-dose aclarubicin, a differentiation-induction therapy for MDS and atypical leukemias in humans, was administered. Hematological improvement was observed, and the dog lived for 809 days after the first presentation.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/10580906/