Peer-reviewed veterinary case report
Long-term safety and benefits of oclacitinib for dogs with allergic
By S. Cosgrove et al.·Published in Veterinary dermatology (Print)·2015·View original on Semantic Scholar →
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Original publication title: Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life.
- Species:
- dog
Plain-English summary
A group of 247 dogs with itchy skin due to allergies or atopic dermatitis were treated with oclacitinib, a medication that helps relieve itching. After starting treatment, over 63% of the dogs showed significant improvement in their itching and skin condition within 90 days, and more than 91% of owners reported a better quality of life for their pets. While some dogs experienced minor issues like urinary tract infections and vomiting, overall, the medication was safe and well-tolerated. Many dogs continued to benefit from oclacitinib for up to 630 days, making it a promising option for long-term management of allergic skin problems.
People also search for: dog itching treatment · oclacitinib for dog allergies · allergic dermatitis in dogs · dog skin problems medication
Abstract
BACKGROUND Oclacitinib is safe and effective for treating dogs with pruritus associated with allergic and atopic dermatitis, based on randomized clinical trials of up to 4 months duration. HYPOTHESIS/OBJECTIVES This study assessed long-term safety, efficacy and quality of life of oclacitinib-treated dogs enrolled in a compassionate use programme. ANIMALS Two hundred and forty-seven client-owned dogs with allergic skin disease that had previously benefited from oclacitinib therapy. METHODS Dogs were enrolled in an open-label study at 26 veterinary clinics. Dogs received 0.4-0.6 mg/kg oclacitinib twice a day for 14 days, then once a day for up to 630 days. Assessments were performed at ~90 day intervals. Owners completed a quality-of-life survey and assessed pruritus using a Visual Analog Scale (VAS) at each clinic visit. Veterinarians assessed dermatitis using a similar VAS. Abnormal health events, concomitant medication and clinical pathology results were summarized. RESULTS Visual Analog Scale scores showed improvement from baseline at all time points. The percentage of dogs showing ≥50% reduction from baseline on day 90 was 63.9% for pruritus and 66.4% for dermatitis. Owners saw a positive impact on quality of life in >91% of all dogs. Urinary tract infection/cystitis, vomiting, otitis, pyoderma and diarrhoea were the most frequently reported (>5% of dogs) abnormal clinical signs. Haematology and serum chemistry means remained within the normal reference ranges. Concomitant medications were well tolerated. CONCLUSIONS AND CLINICAL IMPORTANCE Results indicated that oclacitinib was safe and efficacious for long-term use and improved the quality of life for dogs in this study.
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/25688708