Peer-reviewed veterinary case report
Long-term oral CBD effects on eye health in healthy dogs
By Jost, Haley E et al.·Published in Veterinary ophthalmology·2024·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Long-term effect of oral cannabidiol administration to healthy adult dogs on tear production, intraocular pressure, and tear concentrations.
- Species:
- dog
Plain-English summary
A group of healthy Beagle dogs was given oral cannabidiol (CBD) to see if it affected their tear production or eye pressure over 36 weeks. The study found that CBD did not change how much tears the dogs produced or their eye pressure, which is good news for safety. CBD was detected in the tears of most dogs receiving the treatment, but it didn't seem to cause any problems. Overall, long-term use of CBD in these dogs was safe and did not impact their eye health.
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Abstract
OBJECTIVE: To determine the chronic effects of oral cannabidiol (CBD) use on tear production, intraocular pressure (IOP), and concentration of CBD in tears of healthy dogs. ANIMALS STUDIED: Eighteen healthy research Beagles. PROCEDURES: This was a masked, placebo-controlled, randomized prospective study. Eighteen dogs were randomly assigned to three groups (six dogs per group) based on daily dosage of oral MCT oil (placebo), CBD 5 mg/kg, and CBD 10 mg/kg. Schirmer tear test (STT-1) and IOP were measured twice daily (7 am and 7 pm) every 4 weeks for 36 weeks. Week 36 tears were collected and analyzed for CBD concentrations (ng/mL) using liquid chromatography/mass spectrometry. A mixed linear model was used as the statistical method and p-value <.05 was considered significant. RESULTS: No significant differences were found between placebo vs. 5 mg/kg vs. 10 mg/kg for STT-1 or IOP (AM and PM). CBD was detected in 10 out of 11 (91%) viable tear samples receiving 5 mg/kg or 10 mg/kg dosages. One sample in the 5 mg/kg group had inadequate tear volume for analysis. The CBD concentration in tears was at or below the lower limit of quantification in placebo group, 4.12-11.2 ng/mL for the 5 mg/kg group, and 6.22-152 ng/mL for the 10 mg/kg group. CONCLUSIONS: Long-term administration of oral CBD in healthy research beagles demonstrates a favorable safety profile regarding ocular tolerability. Oral CBD administration does not appear to affect tear production or IOP over a 36-week period. This is the first canine study positively identifying concentrations of CBD in tears following oral administration.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38032014/