Peer-reviewed veterinary case report
Long-term effects of ciclosporin and oclacitinib in dogs with atopic
By Herrmann, Ina et al.·Published in Veterinary dermatology·2023·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Long-term effects of ciclosporin and oclacitinib on mediators of tolerance, regulatory T-cells, IL-10 and TGF-β, in dogs with atopic dermatitis.
- Species:
- dog
Plain-English summary
A group of dogs with atopic dermatitis (a skin allergy) were treated with either ciclosporin or oclacitinib for over nine months to see how these medications affected their immune response. While the dogs on ciclosporin had fewer regulatory T-cells, which help manage immune tolerance, this didn't necessarily mean their treatment was less effective. Both medications seemed to work similarly in managing the dogs' symptoms, and the study suggests that the overall function of these immune cells might be more important than their numbers. More research is needed to understand the long-term effects of these treatments on allergic dogs.
People also search for: dog skin allergy treatment · ciclosporin for dogs · oclacitinib side effects
Abstract
BACKGROUND: Atopic dogs often are managed with allergen-specific immunotherapy (AIT) and concurrent dosages of ciclosporin (CSA) or oclacitinib to alleviate their clinical signs. Both drugs might affect proper tolerance induction by inhibiting regulatory T-cell (Treg) induction. HYPOTHESIS/OBJECTIVES: We evaluated Treg cell numbers and serum interleukin (IL)-10 and transforming growth factor-beta (TGF-β)1 levels in dogs diagnosed with atopic dermatitis (AD) and successfully treated with either CSA or oclacitinib for nine or more months. ANIMALS: We included 15 dogs receiving oclacitinib, 14 dogs treated with CSA, 15 healthy dogs, 13 dogs with untreated moderate-to-severe AD and 15 atopic dogs controlled with AIT. MATERIALS AND METHODS: Peripheral blood CD4+CD25+FOXP3+ T-cell percentages were determined using flow cytometry. Serum concentrations of IL-10 and TGF-β1 were measured by enzyme-linked immunosorbent assay. RESULTS: The percentage of Treg cells in the CSA group was significantly lower in comparison with the healthy group (p = 0.0003), the nontreated AD group (p = 0.0056) or the AIT group (p = 0.0186). There was no significant difference in Treg cell percentages between the CSA and oclacitinib groups, nor between the oclacitinib and the healthy, nontreated AD or AIT-treated dogs. No significant differences were detected in IL-10 and TGF-β1 serum concentrations between the five groups. CONCLUSIONS AND CLINICAL RELEVANCE: Lower Treg cell percentages in the CSA-treated dogs suggest an impact of this drug on this cell population; however, it does not necessarily mean that it diminishes tolerance. Functionality and cytokine production may be more important than the number of Treg cells. Further studies evaluating the treatment outcome of dogs receiving AIT and concurrent drugs are needed to show clinical relevance.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36482868/