Peer-reviewed veterinary case report
Long-term results of giving trilostane twice daily to dogs
By Alenza, Dolores Perez et al.·Published in Journal of the American Animal Hospital Association·2006·Veterinary Teaching Hospital, Spain·View original on PubMed →
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Original publication title: Long-term efficacy of trilostane administered twice daily in dogs with pituitary-dependent hyperadrenocorticism.
- Species:
- dog
Plain-English summary
A group of 44 dogs with pituitary-dependent hyperadrenocorticism (a condition that causes excessive hormone production) were treated with a medication called trilostane, given twice a day. The dogs started on an average dose of 3.1 mg/kg and continued on a slightly adjusted dose of 3.2 mg/kg. The treatment was found to be effective and safe, with the dogs living an average of about 930 days after starting the medication. This study suggests that giving trilostane twice daily can be beneficial for managing this condition in dogs.
People also search for: dog Cushing's disease treatment · trilostane for dogs · pituitary-dependent hyperadrenocorticism in dogs
Abstract
Trilostane is considered an efficacious and safe medication for canine pituitary-dependent hyperadrenocorticism (PDH). Its recommended frequency of administration is once daily. In this prospective study, the efficacy, toxicity, and long-term outcome of trilostane administered twice daily per os were evaluated in 44 dogs with PDH. Mean initial dose was 3.1 mg/kg q 12 hours, and mean final dose was 3.2 mg/kg q 12 hours. The final total daily dose was lower than previously reported for once-daily administration. The mean survival time for affected dogs was 930 days.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16822765/