Peer-reviewed veterinary case report
Long-term results of treatment response in 60 dogs
By Hodel, Susan et al.·Published in Journal of veterinary internal medicine·2024·Clinic for Small Animal Internal Medicine·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Long-term evaluation of the initial response to therapy in 60 dogs with chronic inflammatory enteropathy.
- Species:
- dog
Plain-English summary
A group of 60 dogs with chronic inflammatory enteropathy (CIE), which causes digestive issues, were evaluated over a year to see how their treatment responses changed. Initially, many dogs were categorized as needing immunosuppressive therapy, but after a year, most had improved and were switched to a food-responsive category, indicating that dietary changes were effective. In fact, 63% of the dogs that initially struggled with diets showed significant improvement when reassessed. This suggests that trying different diets sooner could help more dogs find relief without needing stronger medications.
People also search for: dog digestive problems treatment · chronic inflammatory enteropathy diet for dogs · food-responsive enteropathy in dogs
Abstract
BACKGROUND: Dogs with chronic inflammatory enteropathy (CIE) are typically classified into food-responsive enteropathy (FRE), antibiotic-responsive enteropathy (ARE), immunomodulator-responsive enteropathy (IRE), and nonresponsive enteropathy (NRE) based on response to therapy(ies). Reassessment of initial categorization (especially IRE and NRE) is lacking. OBJECTIVES: Investigate validity of categorization scheme when reassessed at least 1 year after diagnosis. ANIMALS: Sixty client-owned dogs with CIE. METHODS: Retrospective study. Clinical information was gathered from records and owners from time of diagnosis (T), time of initial response (T), and at least 1 year after diagnosis (T). Category change was defined as a switch between groups. RESULTS: Median disease activity index (CIBDAI) at Twas 9 and reduced significantly to 1 at T(P < .0001). At T, dogs were categorized as: FRE 27/60 (45%, 95% binomial confidence intervals [CI], 0.32-0.58), IRE 30/60 (50%, CI 0.37-0.63), ARE 0/60 (0%), NRE 3/60 (5%, CI -0.01 to 0.11). Seventeen of 27 (63%) FRE dogs had previously had at least 1 unsuccessful diet trial. At T, categorization changed to FRE 44/60 (73%, CI 0.62-0.85), IRE 14/60 (23%, CI 0.13-0.34), ARE 0/60 (0%), NRE 2/60 (3%, CI -0.01 to 0.08). Group changes were found for 24/60 (40%) dogs, largest change was from IRE to FRE (19/24, 79%). Immunosuppressive dosages were administered as sole treatment in 1/30 (3%) IRE dogs at T. CONCLUSIONS AND CLINICAL IMPORTANCE: Chronic inflammatory enteropathy categorization based on initial response to therapy needs reassessment after 1 year. Frequent change from IRE to FRE suggests that dogs initially categorized as IRE might have been initially categorized as FRE if multiple dietary trials had been performed. In our study, antibiotics were not needed to achieve satisfying clinical responses.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39183535/