Peer-reviewed veterinary case report
Long-term evolutionary adaptation of SIVcpz toward HIV-1 using a humanized mouse model.
- Journal:
- Journal of medical primatology
- Year:
- 2022
- Authors:
- Schmitt, Kimberly et al.
- Affiliation:
- Department of Microbiology · United States
- Species:
- rodent
Abstract
Critical genetic adaptations needed for SIV chimpanzee to evolve into HIV-1 are not well understood. Using humanized mice, we mimicked the evolution of SIVcpzLB715 into HIV-1 Group M over the course of four generations. Higher initial viral load, increased CD4T-cell decline, and nonsynonymous substitutions arose suggesting viral evolution.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/36030391/