Peer-reviewed veterinary case report
Long-term hormone replacement treatment in a horse with central diabetes insipidus.
- Journal:
- Journal of veterinary internal medicine
- Year:
- 2020
- Authors:
- Durie, Inge & van Galen, Gaby
- Affiliation:
- Equine Referral Hospital
- Species:
- horse
Plain-English summary
This case involves a 4-year-old male horse that was having serious issues with peeing and drinking a lot, which led to a diagnosis of central diabetes insipidus, a condition where the body doesn't properly regulate water balance. Various treatments were tried, but only a specific type of injection called desmopressin acetate worked to improve the horse's condition by making its urine more concentrated and reducing its thirst and urination. The horse continued to receive this injection daily for at least five years without any side effects or return of the original problems. Overall, this case shows that long-term treatment with desmopressin acetate was successful for managing the horse's diabetes insipidus.
Abstract
This case report describes the clinical presentation, and the diagnostic and therapeutic approaches of a 4-year-old gelding presented with severe polyuria and polydipsia. The horse was diagnosed with central diabetes insipidus. After diagnosis, different therapeutic regimens with intraocular desmopressin acetate (Minirin, Ferring GmbH, Kiel, Germany) (a synthetic arginine vasopressin analog) were tested, but without success. Only the subcutaneous injection of desmopressin acetate (Minirin, Ferring GmbH) led to an increase in urine specific gravity and a decrease in water intake and urine output. Daily subcutaneous treatment with desmopressin acetate (Minirin, Ferring GmbH) was initiated and maintained for at least 5 years. The horse did not develop adverse effects or re-occurrence of the initial complaints. This case report describes successful long-term treatment of central diabetes insipidus in a horse.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31960998/