Peer-reviewed veterinary case report
How tylosin antibiotic affects healthy dogs' gut bacteria and bile
By Manchester, Alison C et al.·Published in Journal of veterinary internal medicine·2019·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Long-term impact of tylosin on fecal microbiota and fecal bile acids of healthy dogs.
- Species:
- dog
Plain-English summary
A group of 16 healthy adult dogs was given an antibiotic called tylosin for 7 days to see how it affected their gut bacteria and bile acids. While the dogs didn’t show any changes in their stool quality, the ones on tylosin had less variety in their gut bacteria and higher levels of certain bile acids after treatment. Even after stopping the tylosin, the gut bacteria didn’t completely return to normal for all dogs. This suggests that while tylosin can help with diarrhea, it may also disrupt healthy gut bacteria for some time.
People also search for: dog diarrhea treatment tylosin · effects of antibiotics on dog gut health · healthy dog fecal microbiota changes
Abstract
BACKGROUND: Tylosin is commonly prescribed to dogs with diarrhea. Orally administered antibiotics may alter the intestinal microbiota, which is responsible for crucial key bile acid (BA) biotransformation reactions. OBJECTIVES: To prospectively evaluate the impact of tylosin administration on fecal microbiota and unconjugated bile acids (UBAs) over time. ANIMALS: Sixteen healthy adult dogs. METHODS: Prospective, randomized controlled clinical trial. Dogs were randomized to receive 20 mg/kg of tylosin or a placebo capsule PO q12h for 7 days while undergoing daily fecal scoring. Fecal samples were collected on days 0, 7, 21, and 63. The microbiota was assessed using quantitative PCR and 16S rRNA gene sequencing. Unconjugated BAs were assessed using gas chromatography-mass spectrometry (GC-MS). RESULTS: Fecal scores were unchanged during placebo and tylosin administration. In the placebo group, no significant changes were observed in fecal microbiota or UBA concentrations. Day 7 samples from tylosin-exposed dogs exhibited decreased bacterial diversity (observed species, Chao1, Shannon, P < .001) characterized by decreases in anaerobes Fusobacteriaceae (linear discriminant analysis [LDA] score, 5.03) and Veillonellaceae (LDA score, 4.85). Primary UBA concentrations were increased at day 21 (median, [range]; 7.42, [0.67-18.77] μg/kg; P = .04) and day 63 (3.49 [0-28.43] μg/kg; P = .02) compared to day 0 (.14 [.03-1.19] μg/kg) in dogs receiving tylosin. At day 63, bacterial taxa were not significantly different compared to day 0, but the extent of microbial recovery was individualized. CONCLUSIONS AND CLINICAL IMPORTANCE: Tylosin causes fecal dysbiosis in healthy dogs with corresponding shifts in fecal UBAs. Changes did not uniformly resolve after discontinuation of tylosin.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31674054/