Peer-reviewed veterinary case report
Long-term safety of stem cell joint injections for severe dog
By Q. Cabon et al.·Published in Frontiers in Veterinary Science·2019·View original on Semantic Scholar →
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Original publication title: Long-Term Safety and Efficacy of Single or Repeated Intra-Articular Injection of Allogeneic Neonatal Mesenchymal Stromal Cells for Managing Pain and Lameness in Moderate to Severe Canine Osteoarthritis Without Anti-inflammatory Pharmacological Support: Pilot Clinical Study
- Species:
- dog
Plain-English summary
A group of 22 dogs with moderate to severe arthritis received injections of special cells (mesenchymal stromal cells) directly into their joints to help reduce pain and improve movement. Most dogs showed significant improvement in their mobility for up to six months after the first injection, and some received a second injection six months later, maintaining benefits for up to a year. While a few dogs experienced mild, temporary reactions at the injection site, there were no serious side effects reported over the two-year follow-up. Overall, 75% of dog owners were satisfied with the results of the treatment.
People also search for: dog arthritis treatment · mesenchymal stromal cells for dogs · dog joint pain injection · improving dog mobility arthritis · canine osteoarthritis management
Abstract
Objective: To explore the long-term safety and efficacy of canine allogeneic mesenchymal stromal cells (MSC) administered intra-articularly as single or repeated injections in appendicular joints of dogs affected by moderate to severe refractory osteoarthritis. Study Design: 22 pet dogs were recruited into a non-randomized, open and monocentric study initially administering one cellular injection. A second injection was offered after 6 months to owners if the first injection did not produce expected results. Materials and Methods: Anti-inflammatory treatment (if prescribed) was discontinued at last one week before the onset of treatment. Each injection consisted of at least 10 million viable neonatal allogeneic mesenchymal stromal cells obtained from fetal adnexa. Medical data was collected from veterinary clinical evaluations of joints up to 6 months post-injection and owner's assessment of their dog's mobility and well-being followed for a further 2 years when possible. Results: Mild, immediate self-limiting inflammatory joint reactions were observed in 5/22 joints after the first injection, and in almost all dogs having a subsequent injection. No other MSC-related adverse medical events were reported, neither during the 6 months follow up visits, nor during the long-term (2-years) safety follow up. Veterinary clinical evaluation showed a significant and durable clinical improvement (up to 6 months) following MSC administration. Eight dogs (11 joints) were re-injected 6 months apart, sustaining clinical benefits up to 1 year. Owner's global satisfaction reached 75% at 2 years post-treatment Conclusion: Our data suggest that a single or repeated intra-articular administration of neonatal MSC in dogs with moderate to severe OA is a safe procedure and confer clinical benefits over a 24-month period. When humoral response against MSC is investigated by flow cytometry, a positive mild and transient signal was detected in only one dog from the studied cohort, this dog having had a positive clinical outcome.
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/30805348