Peer-reviewed veterinary case report
Dog with rare liver tumor lived over 2 years after toceranib treatment
By Ichimata, Masanao et al.·Published in The Journal of veterinary medical science·2021·Japan Small Animal Cancer Center, Japan·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Long-term survival in a dog with primary hepatic neuroendocrine tumor treated with toceranib phosphate.
- Species:
- dog
Plain-English summary
A 12-year-old male French bulldog was brought to the vet with stomach issues and was found to have a liver mass and other related problems. After tests showed the mass was likely a rare type of cancer called a primary hepatic neuroendocrine tumor, the dog was treated with a medication called toceranib phosphate. Remarkably, the dog lived for over 25 months after starting treatment, which is a significant outcome for this type of cancer. This case highlights the potential effectiveness of toceranib phosphate in treating this rare tumor in dogs.
People also search for: dog liver cancer treatment · French bulldog stomach issues · toceranib phosphate for dogs
Abstract
Primary hepatic neuroendocrine tumors (PHNETs) are rare in dogs, and limited information exists about the treatment of these tumors. A 12-year-old castrated male French bulldog was presented to our clinic with gastrointestinal signs. Diagnostic tests revealed increased hepatic enzyme levels, a mass in the hepatic quadrate lobe, multiple intrahepatic nodules, and enlarged hepatic hilar lymph nodes. The liver mass was diagnosed cytologically as a malignant epithelial tumor suspected to be of neuroendocrine origin. The dog was treated with single-agent toceranib phosphate (TOC) and survived 25.1 months after the initial presentation. On necropsy, a liver mass was found and was subsequently diagnosed as a PHNET on histopathology. To the best of our knowledge, this is the first report of long-term survival in a dog with PHNET treated with TOC.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34408099/