Peer-reviewed veterinary case report
Looking into the cholesterol crystal ball: is complement the answer?
- Journal:
- Kidney international
- Year:
- 2024
- Authors:
- Noris, Marina & Remuzzi, Giuseppe
- Affiliation:
- Istituto di Ricerche Farmacologiche Mario Negri IRCCS · Italy
Abstract
Cholesterol crystal embolism (CCE) is a complication of atherosclerosis and can cause microvascular obstruction in multiple organs. Because the consequences may be fatal, and there is no specific treatment, it is crucial to understand the mechanisms and identify treatment strategies. In this issue, Zhao et al., using a mouse model of kidney CCE, demonstrated that inhibition of C5a/C5aR prevented and resolved CCE-induced renal thrombosis and angiopathy. Although these findings must be extended to human condition, they offer hope for management of CCE syndrome.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/39428170/