Peer-reviewed veterinary case report
Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits.
- Journal:
- Brain pathology (Zurich, Switzerland)
- Year:
- 2021
- Authors:
- Rademakers, Rosa et al.
- Affiliation:
- Department of Neuroscience · United States
Abstract
TMEM106B has been recently implicated in multiple neurodegenerative diseases. Here, Rademakers et al. report a late-onset cerebellar Purkinje cell loss and progressive decline in motor function and gait deficits in a conventional Tmem106b-/- mouse model. By using high-power microscopy and bulk RNA sequencing, the authors further identify lysosomal and immune dysfunction as potential underlying mechanisms of the Purkinje cell loss.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/33709463/