Peer-reviewed veterinary case report
Low central venous oxygen linked to death risk in critically ill dogs
By Hayes, G M et al.·Published in The Journal of small animal practice·2011·University of Guelph, Canada·View original on PubMed →
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Original publication title: Low central venous oxygen saturation is associated with increased mortality in critically ill dogs.
- Species:
- dog
Plain-English summary
A study found that critically ill dogs with low central venous oxygen saturation (ScvO2) levels had a higher risk of dying in the hospital. In a group of 126 dogs, those with ScvO2 below 68% were more likely to face poor outcomes, with each 10% drop increasing the risk of non-survival significantly. The researchers noted that ScvO2 is a useful measure for assessing a dog's oxygen delivery and consumption. This information could help veterinarians identify at-risk dogs and potentially improve treatment strategies in intensive care settings.
People also search for: dog critical care survival rate · low oxygen levels in dogs · dog intensive care unit treatment
Abstract
OBJECTIVES: To investigate relationships between central venous oxygen saturation (ScvO(2)) and survival to hospital discharge in dogs. Central venous oxygen saturation is an accessible measure of the balance between systemic oxygen delivery and consumption. METHODS: Prospective observational cohort study, enrolling 126 client-owned dogs with central venous catheters. Central venous oxygen saturation was measured over the 24 hours following intensive care unit admission. Poor outcome was defined as death or euthanasia performed for moribund status. Regression analysis identified independent predictors of non-survival and physiologic parameters associated with central venous oxygen saturation. Area under the receiver operator curve analysis identified a cut-off point of central venous oxygen saturation, below which central venous oxygen saturation decrease was associated with increased mortality risk. RESULTS: Mortality risk was 30·9%. Low central venous oxygen saturation was associated with poor outcome (P<0·05). Area under the receiver operator curve analysis selected a central venous oxygen saturation of 68% as the point below which a fall in central venous oxygen saturation was associated with increased mortality risk. For each 10% drop in central venous oxygen saturation below 68%, odds of non-survival increased by 2·66 times (P=0·0002, 95% confidence interval of odds ratio=1·45 to 4·85). Central venous oxygen saturation was equivalent to lactate in predicting non-survival. Predictors of central venous oxygen saturation (packed cell volume, mean arterial blood pressure, fever, % arterial haemoglobin saturation as measured by pulse oximeter) were consistent with hypothesised physiologic mechanisms. CLINICAL SIGNIFICANCE: Central venous oxygen saturation was a strong mortality predictor. Further work is needed to determine if therapy targeting central venous oxygen saturation can reduce mortality in canine intensive care unit patients.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21797875/