Peer-reviewed veterinary case report
Low dose insulin detemir prevents diabetes in dogs with pituitary
By Miceli, D D et al.·Published in Research in veterinary science·2012·os Animales-Hospital Escuela Medicina Veterinaria·View original on PubMed →
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Original publication title: Low dose of insulin detemir controls glycaemia, insulinemia and prevents diabetes mellitus progression in the dog with pituitary-dependent hyperadrenocorticism.
- Species:
- dog
Plain-English summary
A group of dogs with pituitary-dependent hyperadrenocorticism (PDH) were monitored for signs of diabetes, which can develop due to high cortisol levels. The study found that dogs with elevated blood sugar levels who received a daily low dose of insulin detemir did not progress to diabetes, while most of those who did not receive insulin did develop the disease. This suggests that giving insulin to dogs with PDH and higher blood sugar can help prevent diabetes. The treatment appears effective in managing their condition and keeping them healthy.
People also search for: dog diabetes treatment · insulin for dogs with Cushing's disease · pituitary-dependent hyperadrenocorticism in dogs
Abstract
Diabetes is often associated with pituitary-dependent hyperadrenocorticism (PDH). Hypercortisolism causes insulin resistance and affects β-cell function. The purpose of this study was to test if daily administration of a long-acting insulin analogue during the first month of anti-PDH treatment can prevent progress to diabetes in these animals. Twenty-six PDH dogs were divided into three groups: one group with glycaemia <5.83 mmol/L and two groups with glycaemia >5.83 mmol/L and <9.35 mmol/L, one of which received insulin detemir during 4 months. Dogs with glycaemia <5.83 mmol/L and those with glycaemia >5.83 mmol/L which received insulin did not develop diabetes. In the non-insulin group, 6/7 dogs developed diabetes after the third month. There is a 13-fold higher risk of diabetes in dogs with glycaemia >5.83 mmol/L and no insulin treatment. Administering insulin detemir to dogs with PDH and glycaemia >5.83 mmol/L could prevent progression to diabetes.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21807392/