Peer-reviewed veterinary case report
Low mupirocin resistance in Staphylococcus pseudintermedius from dog
By Park, Ji-Hyung et al.·Published in Veterinary dermatology·2018·College of Veterinary Medicine, South Korea·View original on PubMed →
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Original publication title: Low prevalence of mupirocin resistance in Staphylococcus pseudintermedius isolates from canine pyoderma in Korea.
- Species:
- dog
Plain-English summary
A study found that a small number of dogs with skin infections caused by Staphylococcus pseudintermedius had a strain that was highly resistant to mupirocin, a topical antibiotic used to treat these infections. Out of 110 dogs tested, most had either meticillin-resistant or meticillin-susceptible strains, but only one showed high resistance to mupirocin. This highlights the importance of monitoring antibiotic resistance in pets, as mupirocin remains a valuable treatment option for many dogs with skin infections.
People also search for: dog skin infection treatment · mupirocin resistance in dogs · Staphylococcus pseudintermedius in pets
Abstract
BACKGROUND: Mupirocin is a topical antibacterial drug used for the treatment of staphylococcal infections, including meticillin-resistant Staphylococcus pseudintermedius (MRSP). The recent emergence of resistance to mupirocin is a major concern in many countries. OBJECTIVES: This study investigated the prevalence and genotype of mupirocin-resistant S. pseudintermedius isolated from pet dogs with pyoderma. SAMPLES: A total of 110 clinical isolates of S. pseudintermedius were collected from dogs with pyoderma (n = 110) between July 2010 and September 2016. All animals were client-owned dogs. METHODS: Low- and high-level mupirocin resistance were evaluated with both the broth microdilution and disk diffusion tests. Mupirocin resistance in S. pseudintermedius isolates was confirmed by genetic analysis of the ileS-2 and naïve ileS genes. RESULTS: MRSP and meticillin-susceptible S. pseudintermedius were detected in 69 and 41 dogs, respectively. One MRSP strain was highly resistant to mupirocin and contained the high-level mupirocin resistance gene ileS-2. There were no low-level mupirocin-resistant isolates. CONCLUSION AND CLINICAL IMPORTANCE: Mupirocin is a useful topical antibacterial for MRSP, but a clinical MRSP isolate that had not previously been exposed to mupirocin exhibited the high-level mupirocin resistance in phenotype and genotype. Therefore, continuous monitoring for mupirocin resistance is important in small animal practice.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29363211/