<i>Phyllanthus emblica</i> L. fruit as potential functional ingredient: From optimized extraction to biological activities evaluation.

Abstract

<i>Phyllanthus emblica</i> L<i>.</i> (<i>P. emblica</i> L.) is a medicine and food homologous plant, whose fruit is acknowledged by the International Health Organization for its high nutritional value. However, eco-friendly and highly efficient methods for extracting the active components from <i>P. emblica</i> L. fruits are currently lacking. In this study, we explored the potential of an eco-friendly enzyme-assisted extraction method for enhancing the extraction of phenolic compounds from <i>P. emblica</i> L., then optimized the extraction process using response surface methodology. After optimization, the contents of gallic acid and total polyphenols reached 33.98 ± 0.15 mg/g and 147.92 ± 1.21 mg GAE/g, respectively. The optimized <i>P. emblica</i> L. extract showed promising anti-inflammatory, antioxidant, and hypoglycemic properties. These findings suggest a viable alternative for obtaining multifunctional extracts from <i>P. emblica</i> L., which have important applications in the functional food and pharmaceutical sectors.