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Peer-reviewed veterinary case report

Luspatercept ameliorates disease phenotype and complications in the Townes mouse model of sickle cell disease.

Journal:
The Journal of clinical investigation
Year:
2026
Authors:
Sezaki, Maiko et al.
Affiliation:
Department of Cell Systems and Anatomy · United States

Abstract

Preclinical data demonstrating that luspatercept mitigates vaso-occlusive and anemia-related complications in the Townes sickle cell model provide a strong rationale for its evaluation in SCD patients.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/41623180/