Lycibarbarspermidine L from Goji Berry Promotes Intestinal Restoration in an Antibiotic-Induced Rat Model through Targeting uc.141A.

Abstract

Oral antibiotics damage gut epithelium while treating infections. Goji berry derives fromL., which is employed as a dietary and tonic herb with the effect of promoting intestinal health. The spermidine compound lycibarbarspermidine L (LBS L) in it can promote intestinal epithelial growth. The purpose of the research is to examine the reparative effects of LBS L against antibiotic-stimulated gut epithelial damage, as well as the processes associated with T-UCR. Intestinal epithelial cells were stimulated with antibiotics to induce injury. The impact of LBS L and T-UCR-related mechanisms was evaluated through cell assays. Ultimately, a rat model of intestinal injury was developed by administering antibiotics. We found that LBS L reversed the intestinal damage caused by antibiotics through modulating uc.141A/miR195-3p. A reduction in intestinal damage was observed in rat models. In conclusion, LBS L ameliorates antibiotic-induced intestinal epithelial cell damage in rats by modulating uc.141A.