Peer-reviewed veterinary case report
Lymphatic invasion predicts worse outcome in dogs with bladder cancer
By Verônica M. Govoni et al.·Published in Open Veterinary Journal·2021·Department of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, Sao Paulo State University – UNESP, Botucatu, SP, 18618-681, Brazil, LY·View original on DOAJ →
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Original publication title: Lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma
- Species:
- dog
Plain-English summary
A group of 32 dogs diagnosed with bladder cancer (urothelial carcinoma) was studied to understand how certain factors affect their survival. It was found that dogs with cancer that invaded lymphatic vessels had a shorter lifespan compared to those without this invasion. Additionally, dogs that received a combination of surgery and the chemotherapy drug vinblastine lived longer than those treated with carboplatin alongside surgery. These findings highlight the importance of lymphatic invasion as a negative indicator for survival in dogs with bladder cancer and suggest that vinblastine may be a more effective treatment option.
People also search for: dog bladder cancer treatment · urothelial carcinoma in dogs · vinblastine for dog cancer
Abstract
Background: Urothelial carcinoma (UC), also known as transitional cell carcinoma, is the most common malignant tumor of the canine urinary bladder and represents a model for studying human bladder cancer. However, the existing literature has limited data on the clinicopathological characteristics of these tumors and their prognostic value. Aim: The aim of this study was to evaluate such factors, correlating them with follow-up, in a group of 32 dogs with bladder UC. Methods: Clinical data of these cases, submitted to São Paulo State University (UNESP) and VetPat Private Laboratory (São Paulo/Brazil), were recorded between January 2000 and November 2019. For each case, formalin-fixed and paraffin-embedded sections were stained with hematoxylin-eosin and histologically evaluated. Survival analysis was performed, and prognostic value of the presence of lymphatic invasion and the treatment used was determined. Results: Dogs with neoplastic lymphatic vessel invasion had lower overall survival compared with those without lymphatic invasion, and dogs that received vinblastine in addition to surgery had higher global survival when compared with animals that received carboplatin in addition to surgery. Conclusions: The results obtained show the importance of further studies regarding the prognostic value of the two factors demonstrated as potential survival predictors, especially the lymphatic vessel invasion.
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Search related cases →Original publication on DOAJ: https://doi.org/10.5455/OVJ.2021.v11.i4.3