Peer-reviewed veterinary case report
Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity.
- Journal:
- Nature genetics
- Year:
- 2005
- Authors:
- Harvey, Natasha L et al.
- Affiliation:
- Department of Genetics and Tumor Cell Biology · United States
- Species:
- rodent
Abstract
Multiple organs cooperate to regulate appetite, metabolism, and glucose and fatty acid homeostasis. Here, we identified and characterized lymphatic vasculature dysfunction as a cause of adult-onset obesity. We found that functional inactivation of a single allele of the homeobox gene Prox1 led to adult-onset obesity due to abnormal lymph leakage from mispatterned and ruptured lymphatic vessels. Prox1 heterozygous mice are a new model for adult-onset obesity and lymphatic vascular disease.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16170315/