Peer-reviewed veterinary case report
How lymphocyte tests identify food allergies in dogs
By Ishida, Rinei et al.·Published in Journal of veterinary internal medicine·2004·Department of Veterinary Internal Medicine, Japan·View original on PubMed →
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Original publication title: Lymphocyte blastogenic responses to inciting food allergens in dogs with food hypersensitivity.
- Species:
- dog
Plain-English summary
Eleven dogs with food allergies were tested to see how their immune systems reacted to certain food allergens. The tests included checking for allergic reactions and how their lymphocytes (a type of white blood cell) responded to these allergens. In most cases, the lymphocyte responses matched the results from a food challenge test, which confirmed the offending foods. When the dogs were put on a special elimination diet, their symptoms improved, and the immune response decreased significantly. This suggests that monitoring lymphocyte responses can help identify food allergies in dogs and guide treatment.
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Abstract
Lymphocyte blastogenic responses against food allergens in dogs with food hypersensitivity were evaluated in this study. Eleven dogs with food hypersensitivity, based on food elimination and oral food provocation tests and allergic responses to food allergens, were examined by various tests such as intradermal testing, antigen-specific IgE testing, and lymphocyte blastogenic responses. The number and kinds of food allergens identified as positive by these tests were compared with the offending food allergens that were found in an oral food provocation test. In 9 (82%) of the 11 dogs with food hypersensitivity, there was close agreement for positive allergens between the results of lymphocyte blastogenic responses and oral food provocation test; however, there was little agreement for intradermal and IgE testing of the positive allergens with those of the oral food provocation test (11% and 31%, respectively). In the 9 dogs, the stimulation indices of lymphocyte blastogenic responses increased to 2.0-10.1 upon food provocation but decreased significantly to 0.7-1.4 upon feeding the elimination diet until clinical signs disappeared. These results indicate that lymphocyte blastogenic responses may fluctuate because of exposure to offending food allergens in dogs with food hypersensitivity. Lymphocytes reactive to food allergens may play an important role in the pathogenesis of food hypersensitivity in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/14765728/