Peer-reviewed veterinary case report
Dog with thyroid and adrenal gland shrinkage from immune disease
By Adissu, H A et al.·Published in Veterinary pathology·2010·Department of Pathobiology, Canada·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Lymphocytic adenohypophysitis and adrenalitis in a dog with adrenal and thyroid atrophy.
- Species:
- dog
Plain-English summary
A 4.5-year-old spayed female Great Pyrenees was diagnosed with thyroid and adrenal gland problems after showing symptoms of lethargy and weight loss. Tests revealed that her pituitary gland was slightly enlarged, and both her adrenal and thyroid glands were underdeveloped. The condition was linked to an autoimmune issue, which is rare in dogs. Treatment options for her conditions typically include hormone replacement therapy, which can help manage her symptoms and improve her overall health.
People also search for: Great Pyrenees thyroid problems · dog adrenal gland disease treatment · autoimmune issues in dogs
Abstract
A 4.5-year-old spayed female Great Pyrenees with hypothyroidism and hypoadrenocorticism had a slightly enlarged pituitary gland and bilaterally atrophic adrenal and thyroid glands. Lymphocytic adenohypophysitis and adrenalitis were found in which B lymphocytes and plasma cells dominated the adenohypophysitis but T cells dominated the adrenalitis. The thyroid gland had extensive follicular atrophy and collapse. The combination of primary hypothyroidism and hypoadrenocorticism resembles type II autoimmune polyendocrine syndrome or Schmidt syndrome in humans. Adenohypophysitis is rare in dogs and not reported in polyendocrine disease in animals.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20807820/