Peer-reviewed veterinary case report
Lyophilized aspirin with trehalose may reduce stomach injuries
By Lin, Lee-Shuan et al.·Published in The Journal of veterinary medical science·2012·Department of Veterinary Surgery, Japan·View original on PubMed →
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Original publication title: Lyophilized aspirin with trehalose may decrease the incidence of gastric injuries in healthy dogs.
- Species:
- dog
Plain-English summary
A group of healthy dogs was given either regular aspirin or a new form of aspirin combined with trehalose to see if it would cause fewer stomach injuries. The dogs that received the lyophilized aspirin with trehalose had less stomach ulceration compared to those that received regular aspirin, while still getting the same effective dose of the medication. This suggests that the new formulation could be a safer option for dogs needing aspirin treatment, potentially reducing the risk of stomach problems.
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Abstract
Trehalose has several novel anti-inflammatory and cell-protective functions. We hypothesized that lyophilized aspirin/trehalose could decrease the severity of aspirin-induced gastropathy. Thirteen dogs were assigned into aspirin, lyophilized aspirin/trehalose, and control groups, and the gastric lesions were assessed on gastroscopy with the modified Lanza scale. Another 6 dogs were used to measure the plasma aspirin concentration by high-performance liquid chromatography after aspirin or lyophilized aspirin/trehalose administration. The results indicated that lyophilized aspirin/trehalose induced less gastric ulceration than aspirin despite maintaining therapeutic concentrations of plasma aspirin in both the groups. Lyophilized aspirin/trehalose might be a solution to decrease aspirin-induced gastropathy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22785245/